Qu’est-ce qu’Octaplasma®?
Octaplasma® est fabriqué à partir de plasma poolé recueilli auprès de donneurs aux États-Unis. 1 Le processus de fabrication d’Octaplasma ® garantit que chaque sac de plasma a une teneur normalisée en facteurs de coagulation et en protéines. Il ne contient aucun anticorps impliqué dans la pathogenèse des lésions pulmonaires aiguës post-transfusionnelles (TRALI) et utilise plusieurs étapes dédiées pour éliminer les agents infectieux transmissibles par transfusion, les réactions allergiques et les réactions au citrate. 2 Octaplasma ® est fabriqué par Octapharma AB à Stockholm, en Suède. 3
What is the recommended approach to handling and storing previously thawed plasma?
If the thawed product cannot be used immediately, it is important to let the product reach +37°C, and then let the product rest for some time at room temperature and slowly cool it down to +2-8°C for up to 5 days of storage. This reduces the chance for protein precipitates to form later – especially after 3-5 days.
Why do you recommend warming the contents of the Octaplasma bag to reach approximately +37°C? Why is it important?
Plasma comprises about 90% water. A cocktail of over 1,000 individual proteins plasma makeup 6-8% of plasma; mostly albumin (55-60%), (α, β and γ) globulins (35-38%) and fibrinogen (4-7%). There are also a number of vital regulatory proteins and coagulation factors (<1%) – as well as electrolytes (e.g., Na+ and Cl-), nutrients [e.g., sugars (glucose) and amino acids], fat (e.g., lipids), hormones (e.g., cortisol and thyroxine), wastes (e.g., urea), and dissolved gasses (e.g., O2 and CO2). Therefore, plasma is a complicated, natural, and multifunctional solution.
Plasma proteins have a primary, secondary, and tertiary structure, shaping molecules with specialized functions under different physical conditions. In frozen plasma, these special functions of plasma proteins are in a static state and need to be regained through thawing, being eventually natural and optimal at around +37°C.
Inadequately thawed plasma can result in the aggregation of plasma proteins (precipitate formation). The recommended thawing temperature helps plasma protein maintain its normal folding.
Therefore, Octaplasma must be allowed to be brought to ‘at or around +37°C’. This is true for frozen products as it is for products in a liquid but a refrigerated state. Octaplasma is a high-quality medicinal product. Thaw it adequately at +37°C, use it quickly, thereafter, and it is best not to under- or overheat the product at any time.
What do the barcodes on an Octaplasma® bag denote?
The fixed barcodes (in black in the above image) do not change from lot to lot and are based on product code and blood group. They help Octapharma for internal tracing of the lot.
The variable barcodes (highlighted in purple in the image above) enable tracing of the bag via ISBT 128 standards. The upper variable barcode denotes bag number, and the lower variable barcode denotes expiry date and donor name with collection time, which may be helpful especially for safety reporting and quality issues.
What ABO groups of Octaplasma® are available? If a specific blood group type is not available, what is to be done?
In emergency cases, where a specific blood group type is not available, Octaplasma® blood group AB can be regarded as universal plasma since it can be given to all patients.3
What are the post-thaw recommendations for the storage of Octaplasma®?
Studies have demonstrated comparable clotting factor activities within thawed and stored Octaplasma® in the refrigerator for up to 5 days.33,34,35
Why does Octaplasma® need to be thawed for a minimum of 30 minutes while FP is only thawed for 25 minutes?
Octaplasma® product monograph recommends 30 minutes thawing time at 37°C, since this time is valid for all devices.
It is suggested that hospitals use their judgment based on the thawing device used locally and the number of bags being thawed. Transfuse only fully thawed bags of Octaplasma® which is a clear, yellow solution without cloudiness or precipitates.
