Why do you recommend warming the contents of the Octaplasma bag to reach approximately +37°C? Why is it important?

Plasma comprises about 90% water. A cocktail of over 1,000 individual proteins plasma makeup 6-8% of plasma; mostly albumin (55-60%), (α, β and γ) globulins (35-38%) and fibrinogen (4-7%). There are also a number of vital regulatory proteins and coagulation factors (<1%) – as well as electrolytes (e.g., Na+ and Cl-), nutrients [e.g., sugars (glucose) and amino acids], fat (e.g., lipids), hormones (e.g., cortisol and thyroxine), wastes (e.g., urea), and dissolved gasses (e.g., O2 and CO2). Therefore, plasma is a complicated, natural, and multifunctional solution.

Plasma proteins have a primary, secondary, and tertiary structure, shaping molecules with specialized functions under different physical conditions. In frozen plasma, these special functions of plasma proteins are in a static state and need to be regained through thawing, being eventually natural and optimal at around +37°C.
Inadequately thawed plasma can result in the aggregation of plasma proteins (precipitate formation). The recommended thawing temperature helps plasma protein maintain its normal folding.

Therefore, Octaplasma must be allowed to be brought to ‘at or around +37°C’. This is true for frozen products as it is for products in a liquid but a refrigerated state. Octaplasma is a high-quality medicinal product. Thaw it adequately at +37°C, use it quickly, thereafter, and it is best not to under- or overheat the product at any time.