Why are fewer allergic reactions observed with Octaplasma® as compared to FP?
December 6, 2024
|By WP Admin
A: In a single-center study comparing Octaplasma® to Cryosupernatant plasma (CSP) for large volume plasma exchange in acute TTP, allergic reactions decreased > 60% with use of Octaplasma®.23
Pooling plasma and viral immune neutralization utilized in manufacturing of Octaplasma® reduces allergic reactions by diluting and reducing antibody titres against blood cells and plasma proteins25,26 and by eliminating the highest molecular weight forms of vWF. 27 The risk of alloimmunization or other cell-related reactions is further reduced by size-exclusion and ligand chromatography, a sterile cell filtration process used in Octaplasma® manufacturing.20,28
