A: Octaplasma® is contraindicated in patients with IgA deficiency with documented antibodies against IgA as it may cause anaphylactic and anaphylactoid reactions, in patients with severe deficiency of protein S as it may result in an increased risk of developing blood clots and in patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.3