What is the citrate level in Octaplasma® and what is the resulting clinical implication?
December 6, 2024
|By WP Admin
A: Each 200 mL of Octaplasma® contains between 0.88 – 1.48 g of sodium citrate dihydrate.3 Thus, citrate levels in Octaplasma® are comparable to that in single-donor FFP.10
In a study evaluating Octaplasma® for large volume plasma exchange in acute TTP, the rate of citrate reactions with Octaplasma® was 50% lower than CSP. .22
As with frozen plasma, high infusion rates may drive citrate elevation and lower ionized plasma calcium levels, especially in patients with liver dysfunction. It is therefore recommended that the infusion rate should not exceed 0.020-0.025 mmol citrate/kg body weight/min, which equals to 1 mL Octaplasma®/kg body weight/min.3
