What has the experience been with Octaplasma® in Canada?
December 6, 2024
|By WP Admin
A: Since the introduction of Octaplasma® in Canada over 10 years ago, more than 91000 bags have been infused into more than 1000 patients in clinical settings such as high volume or chronic plasma transfusions such as TTP, atypical Hemolytic Uremic Syndrome (aHUS), when FP is not effective and for clotting factor deficiencies where licensed concentrates are not available28 etc.
In a study where Canadian patients were treated with Octaplasma® for TTP, aHUS, secondary TMA, C3 glomerulonephritis and antibody-mediated transplant rejection, 80% of the 89% who were switched post allergic reaction to FFP or CSP, had stable or improved disease with Octaplasma® with no severe allergic reactions being reported.29
Octaplasma® is approved by Health Canada to be used for complex coagulation deficiencies as in DIC, repeated large volume plasma exchange, severe hepatic failure; emergency substitution such as in hemorrhage and for rapid reversal of oral anticoagulants in case of insufficient vitamin K or impaired liver function.3
